Abstract
Pharmaceuticals and medical devices can interact with drugs by attachment and sorption onto transfusion tubes, filters, and other plastic products, making it challenging to ensure proper dosage. In particular, although the use of plastic products such as dentures and denture adhesives is widespread in the oral cavity, reports examining the interaction between these products and pharmaceuticals are lacking. The authors investigated whether these products interact with oral spray formulations, sublingual tablets, and orally disintegrating (OD) tablets.
Aqueous solutions of 13 different drugs were exposed to an insoluble denture adhesive for 1 h, and the percentage drug adsorption was calculated by measuring the percentage of each drug remaining in solution using 1H-NMR. Following the exposure of each drug to the denture adhesive, nine drugs demonstrated 5% or less adsorption. In contrast, 20% and 45% of valsartan and irbesartan OD tablets, respectively, were adsorbed. Moreover, isosorbide dinitrate and nitroglycerine, both used sublingually, demonstrated 70% and 30% adsorption, respectively. The percentage absorption of each of these drugs was significantly higher than that of the control (P<0.05). Furthermore, the percentage adsorption of these four drugs correlated with the partition coefficient (P<0.05).
These results suggested that the therapeutic effect of sublingual tablets and OD tablets, which are often retained in the mouth, could be potentially reduced in patients in the presence of denture adhesives owing to attachment and sorption. Further investigations are imperative to identify other drugs at risk of adsorption and altered efficacy.
