Abstract
Continuing the investigations of the antigen-antibody reaction using various antigens and antibodies, the author observed the histological changes in the kidney caused by the active immunization of auto-renal extract. On the experimental method, normal rabbits were immunized intraperitoneally with auto-renal suspension prepared by the unilateral nephrectomy. A total of ten times immune injections was executed once weekly, and one or six weeks after the last injection, these rabbits were sacrificed and the histological changes of the remaining kidney were observed. In nine of twelve rabbits, remarkable changes were observed as follows: 1) anemia, dilatation and hyaline thrombosis in the glomerular loops. 2) swelling, degeneration and necrosis on the capillary walls. 3) swelling, degeneration and proliferation of the glomerular epithelial cells. 4) thickening of the Bowman's capsules. 5) degeneration of tubular epithelium and hyaline casts in the tubules. Similar glomerular changes to these glomerulitis that is characterized by degeneration or proliferative changes of the epithelial cells, are observed on the autopsy causes of various disease too, for example, pyelonephritis or tuberculosis of the kidney, and it is suggested that these glomerular changes are caused by the auto-antigen-antibody reaction to the degenerative tubular epithelial cells.
