II Some Correlation of the Respiratory Sensitivity to Acetylcholine or Histamine to Clinical Analysis of Asthmatic Patients

Abstract

In order to know the correlation between respiratory sensitivity and clinical features of asthma, the author elabolated to measure the bronchial sensitivity to acetylcholine or histamine using Tiffeneans' method, and to make clinical analysis of the subjects. The following results were obtained: 1) No correlation was found between the sensitivity to acetylcholine or histamine and allergic, infectious and psychogenic precipitating factors in asthma. 2) No any difference was found in the sensitivities concerned with the age and sex, and the age of the onset of asthma. 3) Duration and severity of asthma appeared to be no influence on the respiratory threshold to acetylcholine and histamine. 4) No significant difference on the sensitivity was observed between the subjects having family history of asthma and that of no family history of it. 5) Hyposensitization therapy did not induce any difference in the sensitivity to acetylcholine and histamine. 6) No seasonal correlation of the sensitivity was observed in so-called seasonal asthma concerning with the season which mostly worse for the subjacts and with the season better for them.