Studies on Relationships between Viral Infections and Attacks of Asthma

Abstract

Relationships between viral infections and asthmatic attacks were studied. About 80 cases were investigated. Serological tests were carried out with the following antigens: respiratory syncytial virus; parainfluenza virus; influenza viruses type A, B; adenovirus group; M. pneumoniae; and coxsackie B group type 1. On the same time CRP, ESR, nasal smear, and throat swab culture were examined. Viral infections were detected in approximately 30% of the cases with asthmatic attacks in December and February, and about 15% in April and July. Following up 6 patients of perennial asthma for half a year, viral infections were demonstrated in 5 of them. In retrospective study the inset of first attack was involved in measles in about 4%. Partially fluorescent antibody technique was applied in the nasal smear. After immunizing the pigeon with parainfluenza virus, the serum having a high antibody titer was obtained. In conclusion, viral infections suggested to play a role in the attacks of asthma.