The Clinical Studies of Plasma Kinin

Abstract

Plasma kinin was studied from the clinical stand point in our lavoratories and the results presented. 1) The value of urinary kinin excretion ranged 5-35 μg per day in healthy persons, and no difference found between healthy persons and patients with various diseases. 2) The circulating plasma kinin was not excreted into the urine, and urinary kinin seemed to be produced in kidney tissue. 3) The kallikrein-kinin system is considered to play a physiological role in regulation of renal function. 4) Bradykininase activity was very strong in circulating blood, especially in liver diseases and in hyperthyroidism. On the other hand, this enzyme activity was markedly low in bronchial asthma. 5) Plasma kinin activity could not be detected in healthy persons. However, this activity was definitely increased in some cases of bronchial asthma, dermatological diseases and pancreatic diseases. 6) Plasma kallikreinogen levels in healthy persons ranged 3.5-4.4 Frey units per ml. In some patients with hyperthyroidism and with hepatitis, low kallikrenogen levels were observed. In some patients with bronchial asthma, however, high levels were found. 7) The levels of plasma kininogen in 10 healthy persons ranged 4.1-6.9 (mean 5.63±0.76)μg/ml. Kininogen I and II were 2.0-2.9 (mean 2.48±0.28)and 2.0-4.0(mean 3.15±0.55)μg/ml. 8) The kinin-forming activity in subcutaneous fluid of exanthema area of dermatological patients elevated more than that of normal control.