1975 Volume 24 Issue 5 Pages 455-457,461
The T- and B-lymphocyte subpopulations, and PHA-P or PWM reactive lymphocytes in the peripheral lymphocytes obtained from the patients with Sjogren's syndrome were examined simultaneously, comparing with those of the normal subjects. The sheep red cell rosette-formation was used as A-lymphocyte marker, and surface immunoglobulin as B-lymphocyte marker. The lymphocyte cultures were performed using PHA-P and PWM as mitogens and the ^3H-TdR incorporation rate was calculated from the per cent of cpm uptake in mitogen-added culture against mitogen-nonadded culture. No remarkable change of T-lymphocytes was obtained between Sjogren's syndrome and normal subjects, while the decrease of PHA-P reactive lymphocytes were observed in the Sjogern's syndrome (P<0.001). The increase of B-lymphocytes and the decrease of PWM reactive lymphocytes were observed in the patients with Sjogern's syndrome who have been histologically demonstrated the massive infiltrations of lymphocytes into the sublingual glands. The correlation between the T- and B-lymphocytes subpopulations and their functions in the circulnatig lymphocytes and in the tissue were discussed in the paper.
