1975 Volume 24 Issue 9 Pages 681-687,690-69
Mite antigen was labelled with ^<125>I and used in double antibody assay of IgG and IgA antibodies in ten patients who were allergic to both of house dust and mite. IgE antibodies were estimated by RAST. Results are as follows. 1)Level of IgE, IgA and IgG antibodies were higher in 10, 10 and 7 out of 10 patients respectively than in patients who were allergic to pollen but not allergic to mite. Markedly high level of both of IgG- and IgA antibodies was noted in two patients, one of which was treated with house dust and the another was not treated with any allergen. 2)IgM antibodies were not detected in patients as far as examined. 3)There was a patient whose immune response except IgE type response was very poor to immunotherapy with mite and house dust, whereas there was a patient whose immune response was very strong without immunotherapy. It was suggested from this observation that there was different distribution of antibodies in different class of immunoglobulins among patients who were similarly allergic to mite when stimulated with antigen. 4)Precipitin to mite seems to be related with IgG antibodies. When the ratio of level of IgG anti-mite antibodies to level of IgE anti-mite antibodies was compared between the group of patients treated with mite and the group of patients treated with house dust, high ratio was frequently observed in the former group.
