サルにおける実験喘息の研究 第1報 : β-Adrenergic Blockadeサルにおけるメサコリン, ヒスタミンに対する気道の反応性について

近江 徹広; 無江 季次; 高橋 誠; 田村 弦; 石原 俊晴; 鈴木 俊介; 藤本 覚; 佐々木 孝夫; 滝島 任

doi:10.15036/arerugi.29.149

STUDIES OF AN EXPERIMENTAL MODEL OF ASTHMA IN MONKEYS : I. Bronchial Responses to Methacholine and Histamine in Monkeys with Beta-Adrenergic Blockade

Tetsuhiro Ohmi, Suetsugu Mue, Makoto Takahashi, Gen Tamura, Toshiharu Ishihara, Shunsuke Suzuki, Satoru Fujimoto, Takao Sasaki, Tamotsu Takishima

Author information

Tetsuhiro Ohmi
The First Department of Internal Medicine, Tohoku University, School of Medicine
Suetsugu Mue
The First Department of Internal Medicine, Tohoku University, School of Medicine
Makoto Takahashi
The First Department of Internal Medicine, Tohoku University, School of Medicine
Gen Tamura
The First Department of Internal Medicine, Tohoku University, School of Medicine
Toshiharu Ishihara
The First Department of Internal Medicine, Tohoku University, School of Medicine
Shunsuke Suzuki
The First Department of Internal Medicine, Tohoku University, School of Medicine
Satoru Fujimoto
The First Department of Internal Medicine, Tohoku University, School of Medicine
Takao Sasaki
The First Department of Internal Medicine, Tohoku University, School of Medicine
Tamotsu Takishima
The First Department of Internal Medicine, Tohoku University, School of Medicine

Keywords: beta-adrenergic blockade, bronchial hypersensifivity, bronchial reversivility, histamine, methacholine

JOURNAL FREE ACCESS

1980 Volume 29 Issue 4 Pages 149-156

DOI https://doi.org/10.15036/arerugi.29.149

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Abstract

Bronchial reactivity to methacholine and histamine in monkeys with beta-adrenergic blockade was studied by measuring respiratory impedance. Propranolol (5mg/kg body weight/day) was given orally for 10 days and the degree of beta adrenergic blockade was assessed by changes in hyperglycemic and chronotropic responses to the injection of adrenaline. Propranolol treatment produced a more distinct beta-adrenergic blockade in cynomolgus than in Japanese monkeys. In both groups, the bronchial responses to histamine challenge by injection or aerosolized administration were not altered after propranolol treatment. Propranolol treatment increased to bronchial reaction to methacholine injection although it showed no significant change to aerosolized methacholine.

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