Abstract
We studied the effect of intravenous administration of protein- or hapten-containing liposomes (OA-LP, DNP-LP) with or without Mitomycin-C(MMC) on IgE antibody formation in BDF_1 mice. Pre-treatment with OA-LP suppressed not only anti-OA IgE antibody formation but also anti-DNP antibody formation irrespective of the co-existence of MMC. On the other hand, only slight suppression of anti-DNP IgE antibody formation was observed with DNP-LP in the absence of MMC. But an enhanced suppressive effect was observed with the addition of MMC in liposomes containing hapten antigen. None of the liposomes tested had any significant suppressive effect on ongoing anti-hapten or anti-protein IgG antibody responses. However, the usefulness of liposomes containing protein antigen with or without MMC is suggested in the control of seasonal aggravation of atopic diseases. The suppressive effect of the liposomes on the primary IgE antibody formation was observed to similarly affect the secondary reacrion.
