Baker's rhinitis症例における小麦粉抗原に対するIgEおよび末梢血単核細胞応答の解析の試み

春名 威範; 岡野 光博; 藤原 田鶴子; 檜垣 貴哉; 假谷 伸; 牧原 靖一郎; 金井 健吾; 橘 智靖; 松山 祐子; 小松原 靖聡; 直井 勇人; 西﨑 和則

doi:10.15036/arerugi.68.35

Original Article

THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT

Takenori Haruna, Mitsuhiro Okano, Tazuko Fujiwara, Takaya Higaki, Shin Kariya, Seiichiro Makihara, Kengo Kanai, Tomoyasu Tachibana, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Nishizaki

Author information

Takenori Haruna
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Mitsuhiro Okano
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine
Tazuko Fujiwara
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takaya Higaki
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shin Kariya
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Seiichiro Makihara
Department of Otorhinolaryngology, Kagawa Rosai Hospital
Kengo Kanai
Department of Otorhinolaryngology, Kagawa Prefectural Central Hospital
Tomoyasu Tachibana
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Yuko Matsuyama
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Yasutoshi Komatsubara
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Yuto Naoi
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
Kazunori Nishizaki
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Keywords: baker's rhinitis, occupational allergic disease, occupational rhinitis

JOURNAL FREE ACCESS

2019 Volume 68 Issue 1 Pages 35-42

DOI https://doi.org/10.15036/arerugi.68.35

Details

Abstract

Background: Baker's rhinitis is a kind of occupational allergic rhinitis mainly caused by intranasal exposure to wheat and/or rye flour in bakery workers. Continuous exposure to flour may induce the onset of asthma in these patients.

Method: We experienced a case of 34-year-old male with baker's rhinitis without asthma, and investigated responses of IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice.

Result: In the immunoblotting, the patient's IgE reacted with 18 and 30kDa molecules in the extracts of 6 flours used in the bakery. The patient's PBMC produced a substantial amount of IL-5 and IL-13 in response to these flour extracts.

Conclusion: It is suggested that water/salt soluble components of wheat flour selectively induce type 2 cytokines production in baker's rhinitis.

Corresponding author

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