Abstract
Shioda et al. suggested that H.perstussis and the lung tissue infected with H.pertussis (PML) might produce the hypersensitivity in the host and that this hypersensitivity might play a role in the cause of the spastic cough of whooping cough. Experiments based on this idea have been done on mice. Mice actively sensitized with PML showed typical anaphylactic shock when the supernatant of PML was given intravenously ten days after the sensitization and they were desensitized by an intraperitoneal injection of PML 8 hours before challange. From the author's experiments it might be said that the component of the lung tissues may play a greater role than H.pertussis component in producing hypersensitivity of mice by PML. Among the three kinds of hemophilus bacilli, however, H.pertussis was the only one which consistently could produce hypersensitization in these experiments.
