The Distribution of Red Cell Enzyme and Serum Protein Types in a Sample from Iwate, Northern Japan, with the Description of Geographical Cline of Gc Subtypes

Abstract

Blood samples from 500 healthy blood donors of Iwate Prefecture, northern Japan, were examined for polymorphism of the following red cell enzyme and serum protein systems by starch-gel electrophoresis and in part by isoelectrofocusing: ACP, PGMI, ESD, GPT, Hp, Tf and subtypes of PGMI and Gc. The distribution f phenotypes and allele frequencies estimated for each system was essentially similar to those reported in other areas of Japan. However, when the data of Gc subtypes thus far reported in Japan excluding Okinawa Islands are compared, statistically significant geographical cline was detected for GC*1F and GC*2 alleles.