Abstract
Literatures of vasodilator therapy in inner ear diseases were reviewed. Effects of various vasodilating agents on cochlear blood flow were studied in the guinea pig utilizing an electrical impedance plethysmograph.
The animal experiment indicated α-adrenergic blocking agents, carbon dioxide, nitrites, papaverine, dipyridamole and hydralazine as effective vasodilators of the inner ear vessels. Beta-adrenergic agents, parasympathomimetic agents and nicotinic acid were not favorable vasodilators in the inner ear. A restriction was suggested in use of plasma kinins, histamine and betahistine in inner ear vasodilating therapy.
