The Experimental Study of the Side Effect of Lividomycin on the Inner Ear

Abstract

The side effect of lividomycin a new aminoglucoside antibiotics-on the inner ear was studied using the guinea pigs, and the results were discussed and compared with that of kanamycin, lividomycin was injected every day for 40 to 150 days intramuscularly. Preyer's pinna reflex was used for determination of hearing loss.
The lowest sound pressure enable to arise the pinna reflex was measured in the pure tone of 125 to 8, 000Hz every 5 days. After physical examination. pathological change of hair cells of the organ of Corti was observed histologically with silverstain surface preparation method.
Though the pattern of the side effect of lividomycin on the inner ear was almost same as that of kanamycin, the ototoxity of lividomycin was somewhat milder than that of kanamycin.
In its clinical use, it is necessary to take care of the occurence of ototoxity like as other aminoglucoside antibiotics.