Abstract
The disorder of the inner ear induced by injection of SM and KM to the facial nerve through stylomatoid foramen was studied functionally by caloric test and brain stem evoked response. Surface specimens of the vestibular organ and the organ of Corti of guinea pigs were studied.
The injection dose of SM and KM was about 0.03ml of 60mg/ml, 30mg/ml, 15mg/ml, 8mg/ml, and 4mg/ml respectively.
The guinea pigs were tested by BSR using 1 cycle tone of 4, 000Hz, 8, 000Hz, 16, 000Hz, 20, 000Hz as auditory stimuli.
The results were as follows:
1) When the concentration was over 60mg/ml, all the inner ear was damaged and when 4mg/ml was injected, a few disorder can be found. The higher the concentration, the more the damage of the inner ear increased.
2) The cause of disorder correlated with the ototoxic drugs infiltration. It runs along the facial nerve centrally and goes into cochlear and vestibular nerve through anastmosis in the inner ear canal. The shorter the distance between the anastmosis and the organ, the more the damage increased.
There was no differences of the results between KM and SM in this study.
