Abstract
The endocochlear dc potential was recorded in normal and Kanamycin pretreated guinea pigs after Nitromin administration. In Kanamycin pretreated guinea pigs, whose Pryer reflex had already disappeared, endocochlear dc potential did not decrease at all. On the other hand, in Kanamycin pretreated guinea pigs, whose Pryer reflex remained within normal threshold, endocochlear dc potential decreased as in normal guinea pigs. These findings suggest us that organ of Corti may play an important role in the diminution of endocochlear dc potential after Nitromin administration. Kanamycin may affect on the permeability of the capillary wall for Nitromin in the cochlea. This hypothesis should be investigated in the future.
