Evoked Otoacoustic Emission in Guinea pigs

Effect of Jurosemide

Abstract

After recording evoked otoacoustic emissions (e-OAE) to click in guinea pigs by using ILO88 which was made by Kemp and Bray for easy recording and analysis of e-OAE, the changes after intravenous administration of furosemide (30mg/kg or 50mg/kg) were examined. The wave of e-OAE could be detected from 20 of 24 ears. After i.v. injection of furosemide (30mg/kg), e-OAE powers (total echo power and highest peak power in FFT pictures) were decreased quickly and showed minimum values after 5-10 minutes. Then they were increased rapidly and recovered normaly within 60 minutes after injection. On the other hand, e-OAE powers of the majority of the ears showed no response during 5-15 minutes after furosemide injection (50mg/kg). Then they recovered slowly as compared with the furosemide (30mg/kg) injection group. Above mentioned changes are similar to those of endocochlear potential (EP) after furosemide injection. From these results, we supposed that EP can contribute to the generation mechanism of e-OAE.