The Mutation in the Mitochondrial Genome of the Out-patients with Hearing Impairment

Abstract

To search for mutations in mitochondrial genomes among the out-patients with hearing impairment, we investigated the mutations, A1555G, A3243G, A7445G and 7472insC of the mitochondrial genome. Five out of 160 patients, one with the A1555G mutation and four with the A3243G mutation, who comprised approximately 3% of the total patients had a mutation in their mitochondrial genome. The clinical features of these 3 patients are shown.