Biocontrol Science
Online ISSN : 1884-0205
Print ISSN : 1342-4815
ISSN-L : 1342-4815
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Suppression of Feline Calicivirus Replication Using Small Interfering RNA Targeted to Its Polymerase Gene
SATOSHI TAHARAGUCHITAKAHISA MATSUHIROHAYATO HARIMAATSUKO SATOKYOKO OHESACHI SAKAITOSHIKAZU TAKAHASHIMOTONOBU HARA
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2012 Volume 17 Issue 2 Pages 87-91

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Abstract

Feline calicivirus (FCV) is a pathogenic microorganism that causes upper respiratory diseases in cats. Recently, an FCV infection with a high mortality rate has been confirmed, and there is need to develop a treatment for cases of acute infection. We evaluated whether the replication of FCV could be prevented by RNA interference. For this study, we designed an siRNA targeted to the polymerase region of the strain FCV-B isolated from a cat that died after exhibiting neurological symptoms. Cells transfected with siR-pol dose-dependently suppressed the replication of FCV-B. siR-pol suppressed its replication by suppressing the target viral RNA.

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© 2012 The Society for Antibacterial and Antifungal Agents, Japan
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