Synthesis of (R)-and (S)-13-Hydroxy-10-oxo-trans-11-octadecenoic Acid and Their Antimutagenic Activity

Abstract

(R)-and (S)-13-Hydroxy-10-oxo-trans-11-octadecenoic acid (1) were synthesized from (R)- and (S)-2-[(S)-O-methoxyethoxymethylmandelyloxy] heptanal (2R and 2S) and 10-oxoundecanol tetrahydropyranyl ether (3).(R)-acid showed antimutagenic activity against the UV-induced mutation of Escherichia coli.