The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss
Hyoun-Ju KimDong-Ho KimKenta MagooriShigeru SaekiTokuo T. Yamamoto
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1998 Volume 124 Issue 2 Pages 451-456


The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by “exon shuffling.” Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

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© The Japanese Biochemical Society
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