Lecithin: Cholesterol Acyltransferase Is Insufficient to Prevent Oxidative Modification of Low-Density Lipoprotein

Youhei Murakami; Shin Kamiyama; Zakir H. Howlader; Tokuhisa Yamato; Michio Komai; Yuji Furukawa

Youhei Murakami, Shin Kamiyama, Zakir H. Howlader, Tokuhisa Yamato, Michio Komai, Yuji Furukawa

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Keywords: antioxidation, high-density lipoprotein, lecithin: cholesterol acyltransferase, low-density lipoprotein, oxidation

JOURNAL FREE ACCESS

2002 Volume 131 Issue 1 Pages 17-19

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Abstract

We tried to confirm the antioxidative capability of lecithin: cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.

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