STUDIES ON THE OXIDATIVE DECOMPOSITION OF UROCANIC ACID BY LIVER EXTRACT. I

Abstract

1. Urocanic acid is decomposed by enzyme, prepared from the rabbit liver, under O₂-uptake. This fact became clear by the addition of EDTA to the enzyme solution.
2. When the liver extract was treated with Norit, the partially purified enzyme solution decomposed urocanic acid oxidatively without EDTA.
3. The liver extract of rabbit, administered 0.5 mg. aminopterine daily by injection for 40 days, decomposed urocanic acid oxidatively without EDTA.