1956 Volume 43 Issue 6 Pages 821-826
1. From 5-Hydroxytryptophan the substituted indole was not formed by the extract of E. colt but did not inhibit indole formation from tryptophan. The substituted indole was formed from 5-methyltryptophan.
2. 5-Methyltryptophan was decomposed by the liver extract of rabbit and the cell suspension of Y-strain and gave a kynurenine reaction, but 5-hydroxytryptophan was not decomposed and rather inhibited the kynurenine formation from tryptophan.
3. 5-Methylindole and 7-hydroxyindole were decomposed completely by the Y-strain. Pyrrole, 2-methyl-3-carbethoxypyrrole, 2-methyl-3-carboxypyrrole and 1-methylindole were not decomposed. The benzene nucleus of indole must be important for the opening of pyrrole ring. It was suggested, that the benzene moiety of indole can not be cleaved before the pyrrole ring opens.
