METABOLISM OF PARA-AMINOSALICYLIC ACID

IV. STUDIES ON THE METABOLISM OF META-AMINOPHENOL IN REFERENCE TO THAT OF PARA-AMINOSALICYLIC ACID

Abstract

Metabolism of m-aminophenol in mouse, dog and rabbit were examined by paper chromatography. N-acetylaminophenyl glucuronide, aminophenyl glucuronide, N-acetylaminophenyl sulfate, aminophenyl sulfate and an unidentified compound were excreted in the urine of mouse and rabbit. m-Aminophenyl glucuronide and m-aminophenyl sulfate were excreted in the urine of dogs given m-aminophenol. But unchanged m-aminophenol was not excreted in any case. The metabolic products of m-aminophenol were not recognized in the urine of animals to which PAS was administered, so far as the excreted urine was analysed by means of paper chromatography. These results led us to the conclusion that PAS is not metabolized through m-aminophenol in appreciable amounts.