ON THE EFFECT OF BILE ACIDS ON CARBOHYDRATE METABOLISM
II. EXPERIMENTAL DIABETES INDUCED BY SODIUM CHOLATE
1959 Volume 46 Issue 6 Pages 733-737
Details
1959 Volume 46 Issue 6 Pages 733-737
The dose of 500 to 800mg. per kg. of body weight of sodium cholate were administered to 19 rabbits fasted for 40 to 45 hours prior to the ex-periments. Fourteen rabbits died within 48 hours after the administration, but all of the remaining 5 rabbits became diabetic.
Histological observation revealed the damage of the islets of the pancreas'.
The author wishes to express his thanks to Prof. H. Yoshikawa, Dr. M. Nakao of the Department for their support and encouragement, to Dr. N. Mukai for his aid for histological observation and to members of Kotake's institute for kindly supply of xanthurenic acid.
