Abstract
The process of connective tissue growth in granuloma induced by the subcutaneous injection of alginate into rats was investigated over 100 day period.
Differently from the carrageenin-granuloma reported by Jackson et al., the development of new connective tissue was quite slowly achieved and the reabsorption of collagen fibers was scarcely recognized throughout the experimental period.
The relative amount of aminopolysaccharides associated with developing collagen fibers decreased with maturing or aging of fibers.
The administration of ascorbic acid accelerated considerably the reaction from proline to hydroxyproline, i.e. the formation of collagen fibers.
