EFFECTS OF KANAMYCIN ON THE P³²-PHOSPHATE AND S³⁵-SULFATE INCORPORATION INTO THE KANAMYCIN-SENSITIVE AND KANAMYCIN-RESISTANT CELLS OF MYCOBACTERIUM AVIUM

Abstract

1. Kanamycin inhibits the incorporations of P³² into the nucleic acid and protein fractions and the incorporations of S³⁵ into the TCA-soluble and protein (TCA-insoluble) fractions of the parent sensitive strain of Mycobacterium avium, strain Jucho.
2. The incorporations of P³² and S³⁵ into cellular fractions of the kanamycin-resistant strain are not inhibited by kanamycin. Kanamycin-resistant strain has rapid incorporaiions of P³² and S³⁵ into the nucleic acid and protein fractions. The RNA:DNA ratio is higher in the kanamycin-resistant strain than in the parent sensitive strain.