Stero-bile Acids and Bile Sterols
LXIV. The Isolation and the Chemistry of a New Bile Alcohol, 3α, 7α, 12α, 24ξ, 26-Pentahydroxybishomocholane from Rana Catesbiana Bile
1965 Volume 57 Issue 1 Pages 75-80
Details
1965 Volume 57 Issue 1 Pages 75-80
1. Bile salts of Rana catesbiana, when treat-ed with the dioxane-trichloacetic acid reagent for the isolation of bile alcohols from its sul-fates, yielded a new bile alcohol which is assumed to be 3α, 7α, 12α, 24ξ, 26-penta-hydroxybishomocholane by the chemical re-actions and the nuclear magnetic resonance spectrum.
2. It was verified by synthesis that the new bile alcohol has structure (I) of 3α, 7α, 12α, 24ξ, 26-pentahydroxybishomocholane.
3. A number of unsaturated bile alcohols obtained by alkaline hydrolysis of the same bile were missed in its acidic hydrolyzate.
4. The presence of 3α, 7α, 12α, 24ξ, 26-pentahydroxybishomocholane in the frog bile suggests a mechanism of bile salt forma-tion different from that assumed so far in mammals.
The authors wish to thank Dr. K. Takeda, Director of Shionogi Research Laboratory, Osaka, for his generous help in determination of nuclear magnetic resonance spectra.
