1969 Volume 65 Issue 2 Pages 281-284
1. The fibrin stabilizing factor (FSF) was purified by stepwise elution from a DEAE-cellulose column with Tris and was activated by trypsin [EC 3. 4. 4. 4].
2. Activated FSF showed an autocatalytic activation and activated FSF increased the turbidity of fibrinogen.
3. These results indicate that activated FSF has a proteolytic action and the activa-tion of FSF involves limited proteolysis.