Abstract
The biosynthetic routes to 2-aminoacetophenone and 2-amino-3-hydroxyacetophenone were studied. The former was produced from kynurenine via kynurenamine and the latter from 3-hydroxykynurenine via 3-hydroxykynurenamine in rat liver extracts. The decarboxylation of kynurenine to kynurenamine was catalyzed by the 100, 000×g supernatant fraction of a 0.25M sucrose homogenate of rat liver, and that of 3-hydroxykynurenine to 3-hydroxykynurenamine by the rat liver mitochondrial fraction. The conversion of kynurenamine and 3-hydroxykynurenamine to the corresponding
aminoacetophenones proceeded nonenzymically.
