Specific Inhibition of Macrophage Migration Inhibition Factor by Fucosylated Glycolipid RMF
1979 Volume 86 Issue 3 Pages 773-776
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1979 Volume 86 Issue 3 Pages 773-776
The effects of glycolipids on the interaction of the MIF (migration inhibition factor) with rat macrophages were examined using a migration inhibition assay system. MIF activity was specifically blocked by fucosylated Glycolipid RM [Galαl-3Gal(2-1αFuc)β1-3GaINAcβ1-3Ga1β1-4Glcβ1-lceramide, (1978) J. Biochem. 83, 85-90], but not by Cytolipin R, hematoside, or blood group B active glycolipid [Galα1-3Gal(2-1αFuc)β1-4GlcNAcβ1-3Galβ1-4G1cβ1-lceramide]. Inhibition of MIF activity was proportional to the concentration of Glycolipid RM. These findings suggest that Glycolipid RM acts as a receptor for MIF.
