Dog and Rat Pancreatic Phospholipases A₂: Complete Amino Acid Sequences Deduced from Complementary DNAs

Abstract

We performed molecular cloning of the cDNAs that encode dog and rat pancreaticphospholipases A₂ to predict the primary structures of these enzymes. The deduced amino acid sequences exhibited a highly conservative feature which is common to a group of pancreatic phospholipases A₂ from various animal species. Furthermore, the structures of the signal sequences of dog and rat pancreatic phospholipases A₂ were predicted, although the assignment of the positions cleaved post-translationally is only tentative at the present time.