Abstract
We tried fabrication of the guided bone regeneration (GBR)
membrane in which the osteoanagenesis was possible in
short period by coating a hydroxyapatite (HAp) thin film on
the bioabsorbable polymer sheet. Polylactic acid-glycolic acid
copolymer (PLGA) was used for the membrane. The HAp
thin film was prepared by using a pulsed laser deposition
technique. Biocompatibility of the HAp/PLGA hybrid
membrane was evaluated by cell culture experiment using
osteoblast cell. Also, the clinical simulation test of HAp/PLGA
membrane was carried out by using a femoral defect model
of dog. In the in-vitro cell test, the HAp/PLGA membrane
showed more excellent cell proliferation than the PLGA
membrane. As a result of in-vivo animal test, the HAp/
PLGA membrane showed more excellent osseous conduction
than the PLGA membrane. From the above results, it was
proven that the HAp/PLGA membrane was very useful as
the osseous conduction device in the next generation.
