Abstract
Since medicines and medical devices have been developed and used on different basis of the
laws, it was not easy to develop a hybrid preparation of these and to apply for legal permission.
However, now, there is a need to develop medical preparations with novel functions by combining the
functions of medicines and medical devices. In this section, development examples of apatite-related
devices with various medicines are represented as new hybrid pharmaceutical preparations with high
functional drug release and/or biocompatibility. Examples; drug release from self-hardening apatite
bone cement, creation of osteoporosis condition dependent drug delivery system, cell scaffold
construction study with biodegradable apatite / collagen composite cement and cell activity dependent
drug release mechanism consisting of apatite cement Gene delivery system.
