BIOPHYSICS
Online ISSN : 1349-2942
Review Article
Measurements of the driving forces of bio-motors using the fluctuation theorem
Kumiko HayashiMizue TanigawaraJun-ichi Kishikawa
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JOURNALS FREE ACCESS

2012 Volume 8 Pages 67-72

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Abstract

The fluctuation theorem (FT), which is a recent achievement in non-equilibrium statistical mechanics, has been suggested to be useful for measuring the driving forces of motor proteins. As an example of this application, we performed single-molecule experiments on F1-ATPase, which is a rotary motor protein, in which we measured its rotary torque by taking advantage of FT. Because fluctuation is inherent nature in biological small systems and because FT is a non-destructive force measurement method using fluctuation, it will be applied to a wide range of biological small systems in future.

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© 2012 THE BIOPHYSICAL SOCIETY OF JAPAN
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