Mathematical Modeling of the Barrier Function of the Stratum Corneum and Its Application

Abstract

Mammalian skin works as physical, chemical, and immunological defenses, keeping water inside and nuisances outside. Such barrier function is maintained in stratum corneum, the outermost layer composed of dead cells. We construct a mathematical model of the epidermal structure depending on dermal deformation in order to mathematically understand the mechanisms of homeostasis of the barrier function of the stratum corneum. Our mathematical model consists of Ca²⁺ dynamics, cells dynamics and basal membrane dynamics. Using these mathematical models, we aim at understanding of the homeostatic mechanism of the barrier function of the stratum corneum.