Mathematical Model on Multicellular Dynamics for Simulating Tissue Morphogenesis

Abstract

In epithelial cell sheets, forces generated by individual cells cause deformation, such as elongation, bending, and twisting, resulting in the formation of three-dimensional organs and tissues. Mechanistically analyzing the deformation behavior from the cellular level to the tissue level is necessary to elucidate the morphogenesis mechanism. In this paper, we discuss a vertex model that mechanistically considers the behavior of individual cells and introduce the possibilities for conducting research using this model.