Biomedical Research on Trace Elements
Online ISSN : 1880-1404
Print ISSN : 0916-717X
ISSN-L : 0916-717X
Original Article
Mineral Imbalance in Children with Autistic Disorders
Hiroshi YasudaToshie YonashiroKazuya YoshidaTomiko IshiiToyoharu Tsutsui
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2005 Volume 16 Issue 4 Pages 285-292


In order to investigate any role of minerals in autistic disorders, we measured 24 mineral contents in scalp hair samples of 360 autistic children and compared with those of healthy controls. In the male autistic group aged 4-9 years (N=200), the geometric means of many element levels, namely not only essential minerals such as cobalt, chromium, iodine, molybdenum and phosphorus, but also nickel, boron, cadmium and lead were significantly lower than those in the control group (p<0.001). In contrast, selenium level was significantly higher in the autistic group. On the mercury levels, no significant difference was observed between the two groups, though with a tendency of low concentration in the autistic group. Similar mineral imbalance profiles with a global mineral deficiency were observed in the other autistic groups aged 0-3 and 10-15 years (N=85 and 20) and also in the female autistic groups. In addition, high accumulation of a few elements such as iron, manganese, chromium, copper, sodium, aluminum, cadmium, lead, or mercury was observed in some autistic individuals. These findings indicate that autistic children are suffered from a global mineral deficiency in various trace elements, with some individuals being exposed to a marked accumulation of several elements. Autistic children may be classified to sub-groups, based on their mineral imbalance profile in hair.

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© 2005 by Japan Society for Biomedical Research on Trace Elements
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