BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Original Articles
Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury
Hidetake NagaharaAihiro YamamotoTakahiro SenoHiroshi ObayashiTakashi KidaAmane NakabayashiYuji KukidaKazuki FujiokaWataru FujiiKen MurakamiMasataka KohnoYutaka Kawahito
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2016 Volume 10 Issue 1 Pages 47-53


Allograft inflammatory factor-1 (AIF-1) is a protein expressed by macrophages infiltrating the area around the coronary arteries of rats with an ectopic cardiac allograft. Some studies have shown that expression of AIF-1 increased in a mouse model of trinitrobenzene sulfonic acid-induced acute colitis and in acute cellular rejection of human cardiac allografts. These results suggest that AIF-1 is related to acute inflammation. The current study used bleomycin-induced acute lung injury to analyze the expression of AIF-1 and to examine its function in acute lung injury. Results showed that AIF-1 was significantly expressed in lung macrophages and increased in bronchoalveolar lavage fluid from mice with bleomycin-induced acute lung injury in comparison to control mice. Recombinant AIF-1 increased the production of IL-6 and TNF-α from RAW264.7 (a mouse macrophage cell line) and primary lung fibroblasts, and it also increased the production of KC (CXCL1) from lung fibroblasts. These results suggest that AIF-1 plays an important role in the mechanism underlying acute lung injury.

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© 2016 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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