BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Letter
Analysis of microsatellite instability using Promega panel in dermatofibrosarcoma protuberans
Saki Maeda-OtsukaMyangat Tselmeg MijiddorjIkko KajiharaYuki NishimuraHisashi KanemaruSoichiro SawamuraKatsunari MakinoJun AoiShinichi MasuguchiSatoshi Fukushima
Author information
JOURNAL FREE ACCESS

2022 Volume 16 Issue 2 Pages 176-177

Details
Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm derived from fibroblasts. Although the frequency of microsatellite instability (MSI) in skin cancer is reported to be less than 5%, there is only one report of the status of MMR in DFSP. The only analytical report of microsatellite stability in which Promega panel is not used, showed that the frequency of MSI-high, MSI-low and microsatellite stable (MSS) cases was 13.9% (5/36), 16.7% (6/36) and 69.4% (25/36), respectively. Thus, the aim of this study was to evaluate the status of MMR in 36 patients with DFSP diagnosed at Kumamoto University. MSI analysis using the Promega panel showed that all cases were MSS, which indicated the absence of MSI in DFSP. This result indicates that the status of MMR may not be useful for the potential therapeutic application of pembrolizumab and the pathogenesis of DFSP may not involve MSI.

Related papers from these authors
© 2022 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
Previous article
feedback
Top