THE RADIATION EFFECTS ON FRIEND VIRUS DISEASE (PART I)

Abstract

The Friend virus disease, characterized by enlarged spleen and appearance of abnormal cells in peripheral blood stream, is easily establishable by injecting Friend virus intraperitoneally to experimental mice dd. In this experiment, 80 percent of the dd mice suffered from Friend virus disease died within 100 days. As to the irradiation effects in the process of this disease, several ways of whole body irradiation were employed and enlargement of spleen, mortality and histological findings were observed. Single and fractionated irradiation were used. The single irradiation of 500 r, 300 r and 200 r, the fractionated irradiation of 500 r total dose (500 r in 5 and 10 days) and 300 r total dose (300 r in 3 and 6 days) were performed. The influences to the mortality were almost negligible except in the single 200 r irradiation group. The suppressive effects on splenomegalia however, were quite remarkable in all irradiated cases especially with the single 500 r irradiation group. The histological findings were compared and discussed.