Abstract
Studies were made on the determination of histological type of cell infiltration and origin of multinucleate giant cells in cytomegalic inclusion body (CIB) disease. The materials used were 481 autopsy cases of newborns and infants under 1 year old. The parotid, submaxillary gland, kidney, and liver were examined. Type of cell infiltration was determined after observation of its predilection site, grade of intensity, focal tendency, kinds of infiltrating cells, distribution, presence of lymph folliculoid formation, and multinucleate giant cells. Multinucleate giant cells were occasionally seen in cell infiltration foci of the submaxillary glands with CIB disease. Origin of these cells was considered. Conclusions are as follows: 1) Cell infiltration of CIB disease occurs preferentially in lobules of the parotid and submaxillary gland, cortex of the kidney, and lobules of the liver, than in interlobular tissue, medulla, and Glisson’s capsules. 2) Typical cell infiltration of CIB disease is focal lymphocytic around inclusion cells. 3) Proportion of CIB disease to focal lymphocytic infiltration is considerably large in newborns and infants. 4) Multinucleate giant cells in the submaxillary gland may be formed by fusion of ductal cells.
