STUDIES ON THE ANTITUMOR AND PHARMACOLOGICALLY ACTIVE PRINCIPLES, PRUNACETINS, DERIVED FROM STR. GRISEUS VAR. PURPUREUS STRAIN CD-270

Abstract

New antibiotics which consist of pigment-carbohydrate-protein, prunacetin A and CM -1 (E), were isolated from the culture filtrate of Str. griseus var. purpureus strain CD-270. The prosthetic groups of the substances were related to griseorhodins. Both prunacetin A and CM-1 (E) were active on gram positive bacteria especially on corynebacteria and on HeLa cell culture. The former was active on Ehrlich and Sarcoma-180 solid tumors but the latter was Jess active on the same tumors, although both substances failed to inhibit ascites types of tumors. Both prunacetin A and CM- 1 (E) showed marked hypotensive effect on rabbit blood pressure accompanied by the change of respiration. The latter was rather active on the hypotensive effect than the former. Furthermore, remarkable amelioration of the hypotension by bilateral vagotomy was observed by the administration of synthetic adrenocortical hormone. The details on the taxonomic study of strain CD-270, on the production, isolation and purification of active substances, on their physicochemical characteristics and on their biological properties are described.