Abstract
An experimental and clinical study on DI-22 a fat emulsion for intravenous infusion and the first such product to be developed in Japan is presented. DI-22 consists of linoleic acid oleic acid, palmitic acid and linolenic acid which is made isotonic with glycerol. The size of the fat particles are less than 1.0 µ, in diameter and are uniform in shape. The fluctuation of hemoglobin and hematcrit was the same as that of Intralipid and no anemia was observed. The triglyceride curve also was the same as that of Intralipid with neither increase nor accumulation of the product. No remarkable changes were noted in the phospholipid values and plasma fat elimination from the blood stream was found to be very satisfactory when given at a speed of 40 drops per minute (100 150 ml per hour). The side effects were very mild with nausea noted in one case, phlebitis in one case and a peculiar odor experienced in 3 cases out of the 30 cases. No sign of over-loading syndrome was observed and the liver and thrombo-test values were within normal limits. No toxicity was noted. It is concluded that DI-22 is not only safe for clinical use but is valuable for studies of metabolic changes to be made in the future.
https://ror.org/058548196 
