INCIDENCE OF CYTOMEGALIC INCLUSION DISEASE

Abstract

The incidence of cytomegalic inclusion disease (age distribution, sex difference, and site of inclusion bodies) was studied with autopsy cases. The postnatal infection was considered to be more important than the transplacental one. The sex difference did not seem to be significant. There were some differences in the site of inclusion bodies between infants and adults. Cytomegalic inclusion (CMI) disease is characterized histologically by the formation of a large intranuclear and many small intracytoplasmic inclusion bodies in the infected cell which usually is markedly enlarged. The incidence of this disease has been investigated by some authors, some with their own and some others with collected cases from Iiteratures1-8). This disease affects newborns and infants much more frequently than youths and adults. The CMI bodies are found particularly in the salivary gland, but generalized infection can not rarely be noticed. In this paper, the incidence of CMI disease, including age distribution, sex difference, and site of CMI bodies, was precisely studied using our autopsy cases. It was attempted to see which one of the postnatal or transplacental infection was more important, and whether there was any difference in the site of CMI bodies between infants and adults.