STUDIES WITH CARCINOGEN-INDUCED MAMMARY CARCINOMA OF THE RAT The Trial of Auto-Immunization to Inhibit Tumor Formation after the Surgical Removal of Tumors

Abstract

Auto-immunization treatment of carcinogen-fed rats using homogenates of carcinogen induced tumors did not have any adverse effect on new tumor formation and growth as well as local recurrences. Auto-immunization treatments did not change the degree or nature of the inflammatory reaction observed in carcinogen-induced tumors. Auto-antibodies against carcinogen induced tumor tissue antigen could not be demonstrated in sera to any significant extent. However, the detection of lymphocytic infiltration of various intensity in the stroma of the tumor suggested that host definsi mechanism may involve in the course of development this authochtonous tumor.