Spectrophotometric Determination of Famotidine and Its Related Compounds in Pharmaceutical Preparations Using o-Carboxyphenylfluorone -Palladium(II) Complex

Abstract

A novel spectrophotometric method was established for the determination of famotidine (FAM) and its related drugs. The method is based on fading reactions of ternary complex formation among palladium(II), o-carboxyphenylfluorone and hexadecyltrimethylammonium bromide (HTAB). In the determination of FAM, Beer's law is obeyed in the range of 0.01∼0.7 μg cm⁻³. The apparent molar absorptivity and the relative standard deviation were 6.36 × 10⁵ dm³ mol⁻¹ cm⁻¹ and 1.89% (n = 6), respectively. The method was successfully applied to assays of FAM and other H₂ receptor antagonists in pharmaceutical preparations. The proposed method should be useful for a simple and sensitive determination FAM and its related drugs.