Study of Purity Determination of Organic Compounds with 60 MHz Benchtop NMR

Abstract

Since quantitative values on the basis of a nucleus can be obtained by nuclear magnetic resonance (NMR) spectroscopy, the quantitative NMR technique requires no identical standard. For this reason, it is expected to be a universal quantitative method. However, the quantification using an NMR requires a high resolution NMR spectrometer in NMR measurement. In this paper, we discuss the quantitative NMR method using a benchtop NMR spectrometer with a low magnetic field. We studied the conditions of NMR measurement and data process. The precision of the result was evaluated with approximately 1% using a benchtop spectrometer. Especially, the low S/N and large FWHS of the NMR signals caused low repeatability.