Determination of hypochlorite and N-chloro-5-methyl-3-isoxazole-carboxamide in the Hofman reaction

Abstract

An accurate and simple method for determination of N-chloro-5-methyl-3-isoxazole-carboxamide (N-chloroamide) and a small amount of an excess NaOCl in the Hofmann reaction is described. NaOCl is determined potentiometrically with hydrazine sulphate, followed by the iodometric determination of N-chloroamide. This method shows the relative errors of ±2% for NaOCl and ± 1% for N-chloroamide, and is recommended to be applicable to the reaction control.